منابع مشابه
Mevalonate Pathway: Role of Bisphosphonates and Statins
Aminobisphosphonates and statins act in the same metabolic way. Bisphosphonates are considered the drugs of choice for the treatment of osteoporosis, like statins for the treatment of atherosclerosis. Aminobisphosphonates inhibit cholesterol biosynthesis and this might be relevant for their actions on atherosclerosis too. Recently, HMG-CoA reductase inhibitors (statins), have been correlated to...
متن کاملAntitumor activity of bisphosphonates.
Introduction Bone metastases are a major cause of morbidity for patients with many types of cancer including multiple myeloma, breast cancer, prostate cancer, and other solid tumors. The clinical complications of bone metastases include pain, fracture, spinal cord compression, and hypercalcemia of malignancy. Although there are important differences in the biology of bone metastases from differ...
متن کاملBisphosphonates: mechanisms of action.
T bisphosphonates have been known to chemists since the middle of the 19th century, when the first synthesis occurred in 1865 in Germany (1). Etidronate, the first bisphosphonate to be used to treat a human disease (2), was synthesized exactly 100 yr ago (3). Bisphosphonates were used in industry, mainly as corrosion inhibitors or as complexing agents in the textile, fertilizer, and oil industr...
متن کاملInhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.
We have investigated the docking of a variety of inhibitors and substrates to the isoprene biosynthesis pathway enzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphosphate/dimethylallyl diphosphate isomerase (IPPI) and deoxyxylulose-5-phosphate reductoisomerase (DXR) using the Lamarckian genetic alogorithm program, AutoDock. The docked ligand structures are predicted with a approximat...
متن کاملDisambiguating the bisphosphonates.
The bisphosphonates comprise a class of therapeutic agents that inhibit bone resorption and are frequently used in medicine in the treatment of among others osteoporosis, skeletal metastases from solid tumours, hypercalcaemia of malignancy, multiple myeloma and Paget’s disease [1]. First synthesised in 1865 in Germany, their use had been primarily industrial as these molecules proved to be powe...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2011
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e328335729c